Skip to content Skip to left sidebar Skip to footer

Monkeypox

Monkeypox Update: Second Doses

Monkeypox Update: Second Doses

PDPH is recommending that providers who are currently offering monkeypox vaccine to their patients and individuals at highest risk to begin offering second doses of the JYNNEOS vaccine to patients who have received their first dose intradermally. The second dose is recommended 28 days after the first dose.Currently, it is not recommended that patients who received their first dose subcutaneously be recalled for a second dose. Recommendations for when and at what interval subcutaneous doses should be administered will be shared soon.Patients should be reminded protection from monkeypox is not immediate with one dose. Two doses of the JYNNEOS vaccine are required for full protection and maximum immunity is reached 14 days after the second dose. One dose will provide some protection 14 days after vaccinations, but people should still continue to take precautions against monkeypox during this time.More information is available from PDPH at https://bit.ly/PHLMonkeypoxInfo.
Providers will need to enter order requests by 5 pm on Mondays. If your request is approved, you can expect to receive MPX doses Wednesday or Thursday following your request date.

For further questions, email vaccines@phila.gov.

Monkeypox Inventory Update and Ordering Cadence

Monkeypox Inventory Update and Ordering Cadence

To facilitate the transition to intradermal (ID) administration of the Jynneos Monkeypox (MPX) vaccine, please:
  • Accept all Monkeypox inventory into your inventory location. Use this guide.
  • Complete an inventory reconciliation titled “SubQ to ID Transition,” so that we have an accurate count of the number of vials you have on hand. Use this guide.
  • Email vaccines@phila.gov when the reconciliation is complete so PDPH staff can update your inventory to reflect the number of ID doses you have on hand.
Beginning Monday 08/22, we are moving to a weekly ordering cadence for the MPX vaccine.Providers will need to enter orders by 5 pm on Mondays. If your request is approved, you can expect to receive MPX doses Wednesday or Thursday following your request date.Please remember for your request to be approved you must:
Additional Resources
If you have questions about accessing MPX vaccine, email vaccines@phila.gov.

Monkeypox Update: Switch to JYNNEOS Intradermal Strategy

Monkeypox Update: Switch to JYNNEOS Intradermal Strategy

Due to a shortage of doses, the PDPH recommends that providers switch to intradermal vaccination as soon as possible.

Intradermal administration involves injecting the vaccine superficially between the epidermis and the hypodermis layers of the skin, typically of the inner side of the forearm.
Intradermal JYNNEOS administration can be considered for most adults ages 18 years and older. Exceptions include people with a history of developing keloid scars. It is also recommended that clinicians observe patients after vaccination to monitor for the occurrence of immediate adverse reactions; 15 minutes is suggested for most patients, 30 minutes for persons with a history of anaphylaxis to gentamicin, ciprofloxacin, chicken, or egg protein.
Vaccine Schedule and Dosing Regimens
While JYNNEOS dose availability is currently limited, the recommendation is for providers to begin with a single shot. When there is enough vaccine to administer two shots (a complete dose), the recommended dosing interval between the first and second dose of JYNNEOS vaccine for both the standard (subcutaneous administration) and the alternative (intradermal administration) dosing regimens is 28 days for both.
For further questions, email vaccines@phila.gov.